Publikationen von Prof. Dr. Schäfers

Originalarbeiten

Sommer C, Schäfers M (1998) Painful mononeuropathy in C57BL/Wld mice with delayed Wallerian degeneration: Differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. Brain Res 784:154-162.
George A, Marziniak M, Schäfers M, Toyka KV, Sommer C (2000) Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. Pain 88:267-275.
Schäfers M, Brinkhoff J, Neukirchen S, Marziniak M, Sommer C (2001) Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice. Neurosci Lett 310:113-116.
Sommer C, Lindenlaub T, Teuteberg P, Schäfers M, Hartung T, Toyka KV (2001a) Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy. Brain Res 913:86-89.
Sommer C, Schäfers M, Marziniak M, Toyka KV (2001b) Etanercept reduces hyperalgesia in experimental painful neuropathy. J Peripher Nerv Syst 6:67-72.
Schick B, Brors D, Koch O, Schäfers M, Kahle G (2001) Magnetic resonance imaging in patients with sudden hearing loss, tinnitus and vertigo. Otol Neurotol 22:808-12. | Link |
Brors D, Schäfers M, Schick B, Dazert S, Draf W, Kahle G (2001) Sigmoid and transverse sinus thrombosis after closed head injury presenting with unilateral hearing loss. Neuroradiology 43:144-6. | Link |
Schäfers M, Schmidt C, Vogel C, Toyka KV, Sommer C (2002a) Tumor necrosis factor-alpha (TNF) regulates the expression of ICAM-1 predominantly through TNF receptor 1 after chronic constriction injury of mouse sciatic nerve. Acta Neuropathol (Berl) 104:197-205.
Schäfers M, Geis C, Brors D, Yaksh TL, Sommer C (2002b) Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve. J Neurosci 22:536-545
Schneider C, Gold R, Schäfers M, Toyka KV (2002) Mycophenolate mofetil in the therapy of polymyositis associated with a polyautoimmune syndrome. Muscle Nerve 25:286-8. | Link |
Brors D, Aletsee C, Schwager K, Mlynski R, Hansen S, Schäfers M, Ryan AF, Dazert S (2002) Interaction of spiral ganglion neuron processes with alloplastic materials in vitro. Hear Res 167:110-21. | Link |
Schäfers M, Geis C, Svensson CI, Luo ZD, Sommer C (2003a) Selective increase of tumour necrosis factor-alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve. Eur J Neurosci 17:791-804.
Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS (2003b) Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci 23:3028-3038.
Schäfers M, Sorkin LS, Geis C, Shubayev VI (2003c) Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat. Neurosci Lett 347:179-182.
Schäfers M, Sorkin LS, Sommer C (2003d) Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats. Pain 104:579-588.
Schäfers M, Svensson CI, Sommer C, Sorkin LS (2003e) Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci 23:2517-2521.
Brors D, Bodmer D, Pak K, Aletsee C, Schäfers M, Dazert S, Ryan AF (2003) EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and –B3. J Comp Neurol 462:90-100. | Link |
Brors D, Schäfers M, Bodmer D, Draf W, Kahle G, Schick B (2003) Postoperative magnetic resonance imaging findings after transtemporal and translabyrinthine vestibular schwannoma resection. Laryngoscope 113:420-426. | Link |
Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C (2004) Cyclooxygenase inhibition in nerve injury and TNF-induced hyperalgesia in the rat. Exp Neurol 185:160-168.
Schäfers M, Cain D (2004) Single fiber recording: in vivo and in vitro preparations. Meth Mol Med 99:155-166.
Sommer C, Schäfers M (2004) Mechanisms of neuropathic pain: the role of cytokines. Drug Discov Today: Disease Mechanisms 1:441-448.
Svensson CI, Schäfers M, Jones TL, Powell H, Yaksh TL, Sorkin LS (2005) Spinal blockade of TNF blocks SNL-induced increases in spinal p-p38. Neurosci Lett 379:209-13.
Zelenka M, Schäfers M, Sommer C (2005) Intraneural injection of interleukin-1 and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain. Pain 116:257-63.
Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS (2006).Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain 7:337-45 | Link |
Schäfers M, Neukirchen S, Toyka KV, Sommer C (2008) Diagnostic value of sural nerve biopsy in patients with suspected borrelia neuropathy. JPNS: 2008:13:81-91
Czeschik C, Hagenacker T, Schäfers M, Büsselberg D (2008). Differential modulation of ion channels by TNF-alpha. Neurosci Lett 434:293-298
Schäfers M, Sommer C, Vandenabeele P, Sorkin LS (2008). Selective stimulation of tumor necrosis factor receptor (TNFR)-1 or TNFR2 induces ectopic activity in sensory neurons in vitro and pain-related behaviour after intrathekal application in vivo. Neurosci 157(2):414-23
Yoon, MZ, Katsarava Z, Obermann M, Schäfers M, Liedert B, Dzagnidze A, Kribben, A, Egensperger R, LImmroth V, Diener HC, Thomale J (2009) Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathy. BMC Neurosci. 10:77
Hagenacker T, Czeschik JC, Schäfers M, Büsselberg, D (2010). Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor- α. Brain Res Bull. 81(1):157-63
Geis C, Graulich M, Wissmann A, Hagenacker T, Thomale J, Sommer C, Schäfers M (2010). Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Neuroscience 169(1):463-74
Hagenacker T, Hillebrand I, Büsselberg D, Schäfers M (2010). Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism. Brain Res Bull. 83(5):292-6
Hagenacker T, Hillebrand I, Wissmann A, Büsselberg D, Schäfers M (2010). Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca²+ channels. Eur J Pain 14(10):992-8
Hagenacker T, Schäfer N, Büsselberg D, Schäfers M (2013). Analgesic ineffectiveness of lacosamide after spinal nerve ligation and its sodium channel activity in injured neurons. Eur J Pain. 2013 Jul;17(6):881-92 | Link |
Hagenacker T, Lampe M, Schäfers M (2014). Icilin reduces voltage-gated calcium channel currents in naïve and injured DRG neurons in the rat spinal nerve ligation model. Brain Res. 2014 Apr 4;1557:171-9 | Link |
Leo M, Argalski S, Schäfers M, Hagenacker T (2015). Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats. Mediators Inflamm. 2015;2015:124942
| Link |
Hartlehnert M, Derksen A, Hagenacker T, Kindermann D, Schäfers M, Pawlak M, Kieseier BC, Meyer Zu Horste G (2017). Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II. Sci Rep. 7(1):12518 | Link |
Leo M, Schulte M, Schmitt LI, Schäfers M, Kleinschnitz C, Hagenacker T (2017). Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior. Mediators Inflamm. 2786427. | Link |

Übersichtsarbeiten

Schäfers M, Sommer C (2007). Anticytokine therapy in neuropathic pain management. Expert Rev Neurother. 7(11):1613-27
Üceyler N, Schäfers M, Sommer C (2009). Mode of action of cytokines on nociceptive nerve endings. Brain Res Rev 196(1):67-78
Schäfers M, Sorkin LS (2008). Effect of cytokines on neuronal excitability. Neurosci Lett: 37(3):188-93
Sommer C, Schäfers M (2010). Was gibt es neues beim neuropathischen Schmerz? Aktuelle Neurologie 9:447-454
Schäfers M, Tölle TR (2013). Current therapy of neuropathic pain. Nervenarzt. 84(12):1445-50

Buchbeiträge

Brors D, Schäfers M, Schick B, von Ammon K, Prescher A (2000) Anatomical study of the sellar and parasellar surface structures. In: The center of the skullbase. Eds. Fahlbusch R, Buchfelder M. Einhorn Presse Verlag, Reinbeck, S. 163-169.
Schäfers M (2001) Clinical characteristics of neuropathic pain. In: Pain in peripheral nerve diseases. Eds: Sommer C, Reichmann H. Karger Verlag, Basel, S. 32-35
Schäfers M, Sommer C (2001) Polyneuropathies. In: Pain in peripheral nerve diseases. Eds: Sommer C, Reichmann H. Karger Verlag, Basel, S. 53-94
Brors D, Schäfers M, Schick B, Kahle G, Draf W (2002) Langerhans-Zell-Histozytose mit Beteiligung des Felsenbeins. In: Die Chirurgie der lateralen Schädelbasis. Eds. Bootz F, Strauss G. Springer Verlag, Berlin.
Schäfers M (2003, 2006, 2008) Schmerzhafte Polyneuropathien. In: Therapie neuropathischer Schmerzsyndrome. Ed. Sommer C. UNI-MED Verlag, Bremen, S.79-86
Schäfers M (2005, 2008) Pathophysiologie des Tumorschmerzes. In: Supportive Therapie von Knochenmetastasen. Eds. Schmid P, Possinger K. UNI-MED Verlag, Bremen.
Schäfers M, Sommer C, Sorkin LS. Proinflammatory cytokines and neuropathic pain; retrograde signaling: DRG changes after peripheral nerve injury. In: Immune and glial regulation of pain. Eds. Watkins L, Deleo J, Sorkin LS. IASP Press, Seattle. 2007:II: 85-107
Sorkin LS, Schäfers M. Immune cells in peripheral nerve. In: Immune and glial regulation of pain. Eds. Watkins L, Deleo J, Sorkin LS. IASP Press, Seattle. 2007:I: 3-21
Schäfers M. Schmerztherapie im Alter. In: Das Schmerztherapiebuch. Eds. Diener HC, Maier C. Urban und Fischer 4. Auflage, 2011: 313-318
Schäfers M. Schmerztherapie in Schwangerschaft und Stillzeit. In: Das Schmerztherapiebuch. Eds. Diener HC, Maier C. Urban und Fischer 4. Auflage. 2011: 319-326.
Schäfers M, Hagenacker T, Diener H.C. Periphere und zentrale neuropathische Schmerzen. In: Das Therapie Handbuch. Ed. Sauerbruch, T. Elsevier 5. Auflage. 2011.
Schäfers M. Schmerzhafte Polyneuropathien. In: Therapie neuropathischer Schmerzsyndrome. Eds. C. Sommer. Uni-Med. 4. Auflage 2012: 79-92.
Bingel U, Hagenacker T, Schäfers M. Akuter und chronischer Schmerz. In: Therapie und Verlauf neurologischer Erkrankungen. Eds. T. Brandt, H.C. Diener, C. Gerloff. 6. Auflage. 2012: 97-113.
Schäfers M. Schmerztherapie im Alter. In: Das Schmerztherapiebuch. Eds. Diener HC, Maier C. Urban und Fischer 5. Auflage 2017, S. 354-359.
Schäfers M und Schmidt. Schmerztherapie in Schwangerschaft und Stillzeit. In: Das Schmerztherapiebuch. Eds. Diener HC, Maier C. Urban und Fischer 5. Auflage 2017, S. 362-370.